Flotillin-1 downregulates K+ current by directly coupling with Kv2.1 subunit
نویسندگان
چکیده
منابع مشابه
Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.
Flotillin-1 and flotillin-2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins. Previous studies suggest that budding of flotillin microdomains from the plasma membrane is a tightly regulated process. Here, we demonstrate that endocytosis of flotillins is regulated by the Src family kinase F...
متن کاملH(1) antihistamine drug promethazine directly blocks hERG K(+) channel.
Promethazine is a phenothiazine derivative with antihistaminic (H(1)), sedative, antiemetic, anticholinergic, and antimotion sickness properties that can induce QT prolongation, which may lead to torsades de pointes. Since block of cardiac human ether-a-go-go-related gene (hERG) channels is one of the leading causes of acquired long QT syndrome, we investigated the acute effects of promethazine...
متن کاملStomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.
Lipid rafts are sphingolipid- and cholesterol-rich membrane microdomains that are insoluble in nonionic detergents, have a low buoyant density, and preferentially contain lipid-modified proteins, like glycosyl phosphatidylinositol (GPI)-anchored proteins. The lipid rafts were isolated from human erythrocytes and major protein components were identified. Apart from the GPI-anchored proteins, the...
متن کاملModulation of ventricular transient outward K⁺ current by acidosis and its effects on excitation-contraction coupling.
The contribution of transient outward current (Ito) to changes in ventricular action potential (AP) repolarization induced by acidosis is unresolved, as is the indirect effect of these changes on calcium handling. To address this issue we measured intracellular pH (pHi), Ito, L-type calcium current (ICa,L), and calcium transients (CaTs) in rabbit ventricular myocytes. Intracellular acidosis [pH...
متن کاملSeries Resonance Based Fault Current Limiter with Controlling The Point of Common Coupling Voltage
This paper proposes a novel Fault Current Limiter (FCL) for the application on distribution networks to control voltage sags at the Point of Common Coupling (PCC) during faults. This new FCL is based on series resonance including resonance transformer and series capacitor. So, by proper design of the series resonance LC tank, the fault current is limited to an acceptable level. The FCL operatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein & Cell
سال: 2016
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-016-0276-3